Water → 3-(2,3-Dihydro-1,4-benzodioxin-6-yl)-3-{7-[(methylsulfanyl)methyl]-1H-indol-3-yl}butan-1-ol

Participants

Reaction Conditions

Reaction Steps

A solution of 625 mg (1.47 mmol) of the compound from Example 106A in 3 ml of tetrahydrofuran was added dropwise to 5.14 ml (5.14 mmol) of a 1N solution of lithium aluminum hydride in tetrahydrofuran in 6 ml of tetrahydrofuran at RT under argon. The mixture was stirred at 60° C. for 1 h and then mixed with water and acetonitrile, and the suspension was filtered through kieselguhr. The solvents were removed in a rotary evaporator, and the residue was purified by preparative HPLC (mobile phase: acetonitrile/water gradient). 491 mg (87% of theory) of the title compound were obtained.

Provenance & Evidence