Potassium Cyanide → HCID 58392197, compound

Participants

Reaction Conditions

Reaction Steps

174 mg (2.67 mmol) of potassium cyanide and 8.1 mg (0.07 mmol) of 4-N,N-dimethylaminopyridine were added to 608 mg (1.33 mmol) of the compound from Example 107A in 30 ml of DMSO. The mixture was stirred at 120° C. for 2 h and then concentrated, and the residue was taken up in ethyl acetate, washed with saturated aqueous sodium bicarbonate solution, water and saturated aqueous sodium chloride solution, dried over magnesium sulfate, filtered and concentrated. The crude product was purified by preparative HPLC (RP18 column; mobile phase: acetonitrile/water gradient with addition of 0.1% formic acid) to result in 154 mg (30% of theory) of the title compound.

Provenance & Evidence