Potassium Cyanide → HCID 58392530, compound

Participants

Reaction Conditions

Reaction Steps

176 mg (2.70 mmol) of potassium cyanide and 8.2 mg (0.07 mmol) of 4-N,N-dimethylaminopyridine were added to 664 mg (1.35 mmol) of the compound from Example 108A in 29 ml of DMSO. The mixture was stirred at 120° C. for 1 h and then concentrated, and the residue was taken up in ethyl acetate, washed with saturated aqueous sodium bicarbonate solution, water and saturated aqueous sodium chloride solution, dried over magnesium sulfate, filtered and concentrated. The crude product was purified by preparative HPLC (RP18 column; mobile phase: acetonitrile/water gradient with addition of 0.1% formic acid) to result in 460 mg (81% of theory) of the title compound.

Provenance & Evidence