3-[1-(4-Chlorophenyl)-1-cyclopropylethyl]-7-[(methylsulfonyl)methyl]-1H-indole → 3-[1-(1-Benzothiophen-5-yl)-1-cyclopropylethyl]-7-[(methylsulfonyl)methyl]-1H-indole

HRID 561648Notes

Reaction equation

HRID 561648 reaction equation
[S:1]1C2C=CC(C(C3C4C(=C(CSC)C=CC=4)NC=3)(C3CC3)C)=CC=2[CH:3]=[CH:2]1.Cl[C:28]1[CH:33]=[CH:32][C:31]([C:34]([C:39]2[C:47]3[C:42](=[C:43]([CH2:48][S:49]([CH3:52])(=[O:51])=[O:50])[CH:44]=[CH:45][CH:46]=3)[NH:41][CH:40]=2)([CH:36]2[CH2:38][CH2:37]2)[CH3:35])=[CH:30][CH:29]=1>>[S:1]1[C:28]2[CH:29]=[CH:30][C:31]([C:34]([C:39]3[C:47]4[C:42](=[C:43]([CH2:48][S:49]([CH3:52])(=[O:51])=[O:50])[CH:44]=[CH:45][CH:46]=4)[NH:41][CH:40]=3)([CH:36]3[CH2:37][CH2:38]3)[CH3:35])=[CH:32][C:33]=2[CH:3]=[CH:2]1

Participants

3

Reactant 2

HCID 583923883-[1-(4-Chlorophenyl)-1-cyclopropylethyl]-7-[(methylsulfonyl)methyl]-1H-indoleHCID 583924583-[1-(1-Benzothiophen-5-yl)-1-cyclopropylethyl]-7-[(methylsulfanyl)methyl]-1H-indole

Product 1

HCID 583921893-[1-(1-Benzothiophen-5-yl)-1-cyclopropylethyl]-7-[(methylsulfonyl)methyl]-1H-indole

Procedure

The title compound was prepared starting from 237 mg (0.63 mmol) of the compound from Example 187 in analogy to the synthesis of the compound from Example 209. 144 mg (56% of theory) of the target compound were obtained.

Workup

  1. custom144 mg (56% of theory) of the target compound were obtained

Sources & evidence

ORD record
ord-5181c7d0b7b241b592275897dd7b99ac
Source dataset
uspto-grants-2011_11
Patent number
US08063234B2

Reaction notes

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