3-[1-(1,3-Benzodioxol-5-yl)-1-cyclopropylethyl]-7-[(methylsulfanyl)methyl]-1H-indole → 3-[1-(1,3-Benzodioxol-5-yl)-1-cyclopropylethyl]-7-[(methylsulfonyl)methyl]-1H-indole

HRID 561650Notes

Reaction equation

HRID 561650 reaction equation
[O:1]1C2C=CC(C(C3C4C(=C(CSC)C=CC=4)NC=3)(C3CC3)C)=CC=2[O:3][CH2:2]1.Cl[C:28]1[CH:33]=[CH:32][C:31]([C:34]([C:39]2[C:47]3[C:42](=[C:43]([CH2:48][S:49]([CH3:52])(=[O:51])=[O:50])[CH:44]=[CH:45][CH:46]=3)[NH:41][CH:40]=2)([CH:36]2[CH2:38][CH2:37]2)[CH3:35])=[CH:30][CH:29]=1>>[O:1]1[C:28]2[CH:33]=[CH:32][C:31]([C:34]([C:39]3[C:47]4[C:42](=[C:43]([CH2:48][S:49]([CH3:52])(=[O:51])=[O:50])[CH:44]=[CH:45][CH:46]=4)[NH:41][CH:40]=3)([CH:36]3[CH2:38][CH2:37]3)[CH3:35])=[CH:30][C:29]=2[O:3][CH2:2]1

Participants

3

Reactant 2

HCID 583921043-[1-(1,3-Benzodioxol-5-yl)-1-cyclopropylethyl]-7-[(methylsulfanyl)methyl]-1H-indoleHCID 583923883-[1-(4-Chlorophenyl)-1-cyclopropylethyl]-7-[(methylsulfonyl)methyl]-1H-indole

Product 1

HCID 583922823-[1-(1,3-Benzodioxol-5-yl)-1-cyclopropylethyl]-7-[(methylsulfonyl)methyl]-1H-indole

Procedure

The title compound was prepared starting from 214 mg (0.59 mmol) of the compound from Example 189 in analogy to the synthesis of the compound from Example 209. 162 mg (69% of theory) of the target compound were obtained.

Workup

  1. custom162 mg (69% of theory) of the target compound were obtained

Sources & evidence

ORD record
ord-8026c0c1fd734c929e5196defa23c90d
Source dataset
uspto-grants-2011_11
Patent number
US08063234B2

Reaction notes

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