3-[1-(4-Chlorophenyl)-1-cyclopropylpropyl]-7-[(methylsulfanyl)methyl]-1H-indole → 3-[1-(4-Chlorophenyl)-1-cyclopropylpropyl]-7-[(methylsulfonyl)methyl]-1H-indole

HRID 561652Notes

Reaction equation

HRID 561652 reaction equation
Cl[C:2]1C=CC(C(C2C3C(=C(CSC)C=CC=3)NC=2)(C2CC2)CC)=CC=1.[Cl:26][C:27]1[CH:32]=[CH:31][C:30]([C:33]([C:38]2[C:46]3[C:41](=[C:42]([CH2:47][S:48]([CH3:51])(=[O:50])=[O:49])[CH:43]=[CH:44][CH:45]=3)[NH:40][CH:39]=2)([CH:35]2[CH2:37][CH2:36]2)[CH3:34])=[CH:29][CH:28]=1>>[Cl:26][C:27]1[CH:32]=[CH:31][C:30]([C:33]([C:38]2[C:46]3[C:41](=[C:42]([CH2:47][S:48]([CH3:51])(=[O:50])=[O:49])[CH:43]=[CH:44][CH:45]=3)[NH:40][CH:39]=2)([CH:35]2[CH2:37][CH2:36]2)[CH2:34][CH3:2])=[CH:29][CH:28]=1

Participants

3

Reactant 2

HCID 583921183-[1-(4-Chlorophenyl)-1-cyclopropylpropyl]-7-[(methylsulfanyl)methyl]-1H-indoleHCID 583923883-[1-(4-Chlorophenyl)-1-cyclopropylethyl]-7-[(methylsulfonyl)methyl]-1H-indole

Product 1

HCID 583924303-[1-(4-Chlorophenyl)-1-cyclopropylpropyl]-7-[(methylsulfonyl)methyl]-1H-indole

Procedure

The title compound was prepared starting from 116 mg (0.31 mmol) of the compound from Example 191 in analogy to the synthesis of the compound from Example 209. 98 mg (78% of theory) of the target compound were obtained.

Workup

  1. custom98 mg (78% of theory) of the target compound were obtained

Sources & evidence

ORD record
ord-f93de2d4e43d4a72b545865e16e0a72f
Source dataset
uspto-grants-2011_11
Patent number
US08063234B2

Reaction notes

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