HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-[Cyclopropyl(2,4-difluorophenyl)methyl]-7-[(methylsulfanyl)methyl]-1H-indole → 3-[Cyclopropyl(2,4-difluorophenyl)methyl]-7-[(methylsulfinyl)methyl]-1H-indole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-[Cyclopropyl(2,4-difluorophenyl)methyl]-7-[(methylsulfanyl)methyl]-1H-indole | HCID 58392119 | — |
| Reactant | 3-[(4-Chlorophenyl)(cyclopropyl)methyl]-7-[(methylsulfinyl)methyl]-1H-indole | HCID 58392254 | — |
| Product | 3-[Cyclopropyl(2,4-difluorophenyl)methyl]-7-[(methylsulfinyl)methyl]-1H-indole | HCID 58392112 | — |
Reaction Steps
The title compound was prepared starting from 50 mg (0.15 mmol) of the compound from Example 228 in analogy to the synthesis of the compound from Example 235. 43 mg (82% of theory) of the target compound were obtained as mixture of diastereomers.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08063234B2 |
| Source dataset | uspto-grants-2011_11 |
| ORD ID | ord-39d7c7b834e94f30b06eca39b810d891 |
| Source note | uspto-grants-2011_11 |