HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-[(4-Chlorophenyl)(cyclopropyl)methyl]-7-[(methylsulfinyl)methyl]-1H-indole → 3-[(2-Chloro-4-fluorophenyl)(cyclopropyl)methyl]-7-[(methylsulfinyl)methyl]-1H-indole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-[(4-Chlorophenyl)(cyclopropyl)methyl]-7-[(methylsulfinyl)methyl]-1H-indole | HCID 58392254 | — |
| Reactant | 3-[(2-Chloro-4-fluorophenyl)(cyclopropyl)methyl]-7-[(methylsulfanyl)methyl]-1H-indole | HCID 58392436 | — |
| Product | 3-[(2-Chloro-4-fluorophenyl)(cyclopropyl)methyl]-7-[(methylsulfinyl)methyl]-1H-indole | HCID 58392336 | — |
Reaction Steps
The title compound was prepared starting from 65 mg (0.18 mmol) of the compound from Example 229 in analogy to the synthesis of the compound from Example 235. 68 mg (100% of theory) of the target compound were obtained as mixture of diastereomers.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08063234B2 |
| Source dataset | uspto-grants-2011_11 |
| ORD ID | ord-6230457eb31649329f220869c90851f7 |
| Source note | uspto-grants-2011_11 |