HuagongsheHuagongshe Chemistry Print Report · For research reference only
Morpholine → 4-Morpholinebutanenitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Morpholine | HCID 8083 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 4-Bromobutyronitrile | HCID 21412 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | 4-Morpholinebutanenitrile | HCID 294574 | 94.2% |
Reaction Steps
To a suspension of K2CO3 (8.28 g, 60 mmol) and morpholine (4.35 g, 50 mmol) in acetonitrile (50 mL) was added 4-bromobutyronitrile (7.40 g, 50 mmol) dropwise at rt under N2. The mixture was stirred at rt for 6 h, filtered and concentrated in vacuo to give the title compound (7.26 g, 94.2%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09434695B2 |
| Source dataset | uspto-grants-2016_09 |
| ORD ID | ord-a3afacc638194dbeb24162ab0071b1cb |
| Source note | uspto-grants-2016_09 |