3-[(4-Chlorophenyl)(cyclopropyl)methyl]-6-fluoro-7-[(methylsulfanyl)methyl]-1H-indole → 3-[(4-Chlorophenyl)(cyclopropyl)methyl]-6-fluoro-7-[(methylsulfonyl)methyl]-1H-indole

HRID 561678Notes

Reaction equation

HRID 561678 reaction equation
ClC1C=CC(C(C2CC2)C2C3C(=C(CSC)C([F:18])=CC=3)NC=2)=CC=1.[Cl:25][C:26]1[CH:31]=[CH:30][C:29]([C:32]([C:37]2[C:45]3[C:40](=[C:41]([CH2:46][S:47]([CH3:50])(=[O:49])=[O:48])[CH:42]=[CH:43][CH:44]=3)[NH:39][CH:38]=2)([CH:34]2[CH2:36][CH2:35]2)C)=[CH:28][CH:27]=1>>[Cl:25][C:26]1[CH:31]=[CH:30][C:29]([CH:32]([CH:34]2[CH2:36][CH2:35]2)[C:37]2[C:45]3[C:40](=[C:41]([CH2:46][S:47]([CH3:50])(=[O:49])=[O:48])[C:42]([F:18])=[CH:43][CH:44]=3)[NH:39][CH:38]=2)=[CH:28][CH:27]=1

Participants

3

Reactant 2

HCID 583923763-[(4-Chlorophenyl)(cyclopropyl)methyl]-6-fluoro-7-[(methylsulfanyl)methyl]-1H-indoleHCID 583923883-[1-(4-Chlorophenyl)-1-cyclopropylethyl]-7-[(methylsulfonyl)methyl]-1H-indole

Product 1

HCID 592939413-[(4-Chlorophenyl)(cyclopropyl)methyl]-6-fluoro-7-[(methylsulfonyl)methyl]-1H-indole

Procedure

The title compound was prepared starting from 238 mg (0.66 mmol) of the compound from Example 234 in analogy to the synthesis of the compound from Example 209. 144 mg (55% of theory) of the target compound were obtained.

Workup

  1. custom144 mg (55% of theory) of the target compound were obtained

Sources & evidence

ORD record
ord-709d663b02ad427e9810a59d429620d6
Source dataset
uspto-grants-2011_11
Patent number
US08063234B2

Reaction notes

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