HuagongsheHuagongshe Chemistry Print Report · For research reference only
(4-Chloro-3-fluorophenyl)(4-fluorophenyl)methanol → 3-[(4-Chloro-3-fluorophenyl)(4-fluorophenyl)methyl]-7-[(methylsulfanyl)methyl]-1H-indole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (4-Chloro-3-fluorophenyl)(4-fluorophenyl)methanol | HCID 2757452 | — |
| Reactant | 3-[Bis(4-fluorophenyl)methyl]-7-[(methylsulfanyl)methyl]-1H-indole | HCID 58392127 | — |
| Reactant | 7-[(Methylsulfanyl)methyl]-1H-indole | HCID 58392187 | — |
| Product | 3-[(4-Chloro-3-fluorophenyl)(4-fluorophenyl)methyl]-7-[(methylsulfanyl)methyl]-1H-indole | HCID 58392242 | — |
Reaction Steps
The title compound was prepared starting from 750 mg (4.23 mmol) of the compound from Example 8A and 1.08 g (4.23 mmol) of the compound from Example 176A in analogy to the synthesis of the compound from Example 278. 460 mg (26% of theory) of the target compound were obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08063234B2 |
| Source dataset | uspto-grants-2011_11 |
| ORD ID | ord-23799dc416b248e98b523d39340a070e |
| Source note | uspto-grants-2011_11 |