3-[Bis(4-fluorophenyl)methyl]-7-[(methylsulfanyl)methyl]-1H-indole → HCID 58392218, compound

HRID 561702Notes

Reaction equation

HRID 561702 reaction equation
[CH3:1][S:2][CH2:3][C:4]1[CH:5]=[CH:6][CH:7]=[C:8]2[C:12]=1[NH:11][CH:10]=[CH:9]2.[Cl:13][C:14]1[CH:19]=[C:18]([F:20])[C:17]([CH:21]([C:23]2[CH:28]=[CH:27][C:26]([F:29])=[CH:25][CH:24]=2)O)=[C:16]([F:30])[CH:15]=1.FC1C=CC(C(C2C=CC(F)=CC=2)C2C3C(=C(CSC)C=CC=3)NC=2)=CC=1>>[Cl:13][C:14]1[CH:15]=[C:16]([F:30])[C:17]([CH:21]([C:23]2[CH:28]=[CH:27][C:26]([F:29])=[CH:25][CH:24]=2)[C:9]2[C:8]3[C:12](=[C:4]([CH2:3][S:2][CH3:1])[CH:5]=[CH:6][CH:7]=3)[NH:11][CH:10]=2)=[C:18]([F:20])[CH:19]=1

Participants

4

Reactant 3

HCID 583921273-[Bis(4-fluorophenyl)methyl]-7-[(methylsulfanyl)methyl]-1H-indoleHCID 583921877-[(Methylsulfanyl)methyl]-1H-indoleHCID 58392298HCID 58392298, compound

Product 1

HCID 58392218HCID 58392218, compound

Procedure

The title compound was prepared starting from 490 mg (2.76 mmol) of the compound from Example 8A and 753 mg (2.76 mmol) of the compound from Example 178A in analogy to the synthesis of the compound from Example 278. 140 mg (12% of theory) of the target compound were obtained.

Workup

  1. custom140 mg (12% of theory) of the target compound were obtained

Sources & evidence

ORD record
ord-50fff8da0f9c457d970c7f44a4ab1e56
Source dataset
uspto-grants-2011_11
Patent number
US08063234B2

Reaction notes

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