Trifluoroacetic acid → 3-[(4-Chloro-2-fluorophenyl)(2,4-difluorophenyl)methyl]-7-[(methylsulfanyl)methyl]-1H-indole

Participants

Reaction Conditions

Reaction Steps

The title compound was prepared starting from 750 mg (4.23 mmol) of the compound from Example 8A and 1.15 g (4.23 mmol) of the compound from Example 181A in analogy to the synthesis of the compound from Example 278. A difference was that stirring at 80° C. for two days was followed by addition of 0.33 ml (4.23 mmol) of trifluoroacetic acid and stirring for an additional 16 h. 65 mg (75% purity, 3% of theory) of the target compound were obtained.

Provenance & Evidence