HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 561710Generated: October 26, 2026
(4-Chloro-2-methylphenyl)(4-fluorophenyl)methanol → 3-[(4-Chloro-2-methylphenyl)(4-fluorophenyl)methyl]-5-fluoro-7-[(methylsulfanyl)methyl]-1H-indole
https://huagongshe.com/reaction/561710
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | (4-Chloro-2-methylphenyl)(4-fluorophenyl)methanol | HCID 58392095 | — |
| Reactant | 3-[Bis(4-fluorophenyl)methyl]-7-[(methylsulfanyl)methyl]-1H-indole | HCID 58392127 | — |
| Reactant | 5-Fluoro-7-[(methylsulfanyl)methyl]-1H-indole | HCID 58392227 | — |
| Product | 3-[(4-Chloro-2-methylphenyl)(4-fluorophenyl)methyl]-5-fluoro-7-[(methylsulfanyl)methyl]-1H-indole | HCID 58392221 | — |
Reaction Steps
The title compound was prepared starting from 500 mg (2.56 mmol) of the compound from Example 11A and 706 mg (2.56 mmol) of the compound from Example 83A in analogy to the synthesis of the compound from Example 278. A difference was that stirring at 80° C. was for only 4 h. 616 mg (56% of theory) of the target compound were obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08063234B2 |
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| Source dataset | uspto-grants-2011_11 |
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| ORD ID | ord-80838b15ecb2421eb1318190daec9277 |
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| Source note | uspto-grants-2011_11 |
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