3-[Bis(4-chlorophenyl)methyl]-7-[(methylsulfinyl)methyl]-1H-indole → 4-[(4-Chlorophenyl){7-[(methylsulfinyl)methyl]-1H-indol-3-yl}methyl]benzonitrile

HRID 561713Notes

Reaction equation

HRID 561713 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([C:17]2[C:25]3[C:20](=[C:21]([CH2:26][S:27][CH3:28])[CH:22]=[CH:23][CH:24]=3)[NH:19][CH:18]=2)[C:9]2[CH:16]=[CH:15][C:12]([C:13]#[N:14])=[CH:11][CH:10]=2)=[CH:4][CH:3]=1.ClC1C=CC(C(C2C=CC(Cl)=CC=2)C2C3C(=C(CS(C)=[O:48])C=CC=3)NC=2)=CC=1>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([CH:8]([C:17]2[C:25]3[C:20](=[C:21]([CH2:26][S:27]([CH3:28])=[O:48])[CH:22]=[CH:23][CH:24]=3)[NH:19][CH:18]=2)[C:9]2[CH:10]=[CH:11][C:12]([C:13]#[N:14])=[CH:15][CH:16]=2)=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 583921253-[Bis(4-chlorophenyl)methyl]-7-[(methylsulfinyl)methyl]-1H-indoleHCID 670011584-[(4-Chlorophenyl){7-[(methylsulfanyl)methyl]-1H-indol-3-yl}methyl]benzonitrile

Product 1

HCID 670012154-[(4-Chlorophenyl){7-[(methylsulfinyl)methyl]-1H-indol-3-yl}methyl]benzonitrile

Procedure

The title compound was prepared starting from 60 mg (0.15 mmol) of the compound from Example 281 in analogy to the synthesis of the compound from Example 296. 62 mg (99% of theory) of the target compound were obtained as mixture of diastereomers.

Workup

  1. custom62 mg (99% of theory) of the target compound were obtained as mixture of diastereomers

Sources & evidence

ORD record
ord-8970069405e646ca89de310580e48b23
Source dataset
uspto-grants-2011_11
Patent number
US08063234B2

Reaction notes

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