3-[Bis(4-chlorophenyl)methyl]-7-[(methylsulfinyl)methyl]-1H-indole → 3-[(4-Chloro-3-fluorophenyl)(4-fluorophenyl)methyl]-7-[(methylsulfinyl)methyl]-1H-indole
Reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([C:21]2[CH:26]=[CH:25][C:24]([F:27])=[CH:23][CH:22]=2)[C:9]2[C:17]3[C:12](=[C:13]([CH2:18][S:19][CH3:20])[CH:14]=[CH:15][CH:16]=3)[NH:11][CH:10]=2)=[CH:4][C:3]=1[F:28].ClC1C=CC(C(C2C=CC(Cl)=CC=2)C2C3C(=C(CS(C)=[O:48])C=CC=3)NC=2)=CC=1>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([C:21]2[CH:22]=[CH:23][C:24]([F:27])=[CH:25][CH:26]=2)[C:9]2[C:17]3[C:12](=[C:13]([CH2:18][S:19]([CH3:20])=[O:48])[CH:14]=[CH:15][CH:16]=3)[NH:11][CH:10]=2)=[CH:4][C:3]=1[F:28]Participants
3
Reactant 2
Product 1
Procedure
The title compound was prepared starting from 75 mg (0.18 mmol) of the compound from Example 283 in analogy to the synthesis of the compound from Example 296. 76 mg (98% of theory) of the target compound were obtained as mixture of diastereomers.
Workup
- custom76 mg (98% of theory) of the target compound were obtained as mixture of diastereomers
Sources & evidence
- ORD record
- ord-13e4094f75494c53b53482771a82135e
- Source dataset
- uspto-grants-2011_11
- Patent number
- US08063234B2
Reaction notes
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