3-[Bis(4-chlorophenyl)methyl]-7-[(methylsulfinyl)methyl]-1H-indole → HCID 58392365, compound

HRID 561716Notes

Reaction equation

HRID 561716 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([F:8])[C:5]([CH:9]([C:22]2[CH:27]=[CH:26][C:25]([F:28])=[CH:24][CH:23]=2)[C:10]2[C:18]3[C:13](=[C:14]([CH2:19][S:20][CH3:21])[CH:15]=[CH:16][CH:17]=3)[NH:12][CH:11]=2)=[C:4]([F:29])[CH:3]=1.ClC1C=CC(C(C2C=CC(Cl)=CC=2)C2C3C(=C(CS(C)=[O:49])C=CC=3)NC=2)=CC=1>>[Cl:1][C:2]1[CH:3]=[C:4]([F:29])[C:5]([CH:9]([C:22]2[CH:23]=[CH:24][C:25]([F:28])=[CH:26][CH:27]=2)[C:10]2[C:18]3[C:13](=[C:14]([CH2:19][S:20]([CH3:21])=[O:49])[CH:15]=[CH:16][CH:17]=3)[NH:12][CH:11]=2)=[C:6]([F:8])[CH:7]=1

Participants

3

Reactant 2

HCID 583921253-[Bis(4-chlorophenyl)methyl]-7-[(methylsulfinyl)methyl]-1H-indoleHCID 58392218HCID 58392218, compound

Product 1

HCID 58392365HCID 58392365, compound

Procedure

The title compound was prepared starting from 40 mg (0.09 mmol) of the compound from Example 285 in analogy to the synthesis of the compound from Example 296. 38 mg (92% of theory) of the target compound were obtained as mixture of diastereomers.

Workup

  1. custom38 mg (92% of theory) of the target compound were obtained as mixture of diastereomers

Sources & evidence

ORD record
ord-427e935e0fff457aa79ee7b5dffce688
Source dataset
uspto-grants-2011_11
Patent number
US08063234B2

Reaction notes

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