HCID 58392090, compound → HCID 58392319, compound

HRID 561718Notes

Reaction equation

HRID 561718 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([C:17]2[C:25]3[C:20](=[C:21]([CH2:26][S:27][CH3:28])[CH:22]=[CH:23][CH:24]=3)[NH:19][CH:18]=2)([C:10]2[CH:15]=[CH:14][C:13]([F:16])=[CH:12][CH:11]=2)[CH3:9])=[CH:4][CH:3]=1.ClC1C=CC(C(C2C=CC(Cl)=CC=2)C2C3C(=C(CS(C)=[O:48])C=CC=3)NC=2)=CC=1>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]([C:17]2[C:25]3[C:20](=[C:21]([CH2:26][S:27]([CH3:28])=[O:48])[CH:22]=[CH:23][CH:24]=3)[NH:19][CH:18]=2)([C:10]2[CH:11]=[CH:12][C:13]([F:16])=[CH:14][CH:15]=2)[CH3:9])=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 58392090HCID 58392090, compoundHCID 583921253-[Bis(4-chlorophenyl)methyl]-7-[(methylsulfinyl)methyl]-1H-indole

Product 1

HCID 58392319HCID 58392319, compound

Procedure

The title compound was prepared starting from 300 mg (0.73 mmol) of the compound from Example 289 in analogy to the synthesis of the compound from Example 296. 193 mg (62% of theory) of the target compound were obtained as mixture of diastereomers.

Workup

  1. custom193 mg (62% of theory) of the target compound were obtained as mixture of diastereomers

Sources & evidence

ORD record
ord-5292fe9a5b5045cc850e0c6a50e73f1a
Source dataset
uspto-grants-2011_11
Patent number
US08063234B2

Reaction notes

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