HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-[Bis(4-chlorophenyl)methyl]-7-[(methylsulfinyl)methyl]-1H-indole → 5-Fluoro-3-[(4-fluoro-2-methylphenyl)(4-fluorophenyl)methyl]-7-[(methylsulfinyl)methyl]-1H-indole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-[Bis(4-chlorophenyl)methyl]-7-[(methylsulfinyl)methyl]-1H-indole | HCID 58392125 | — |
| Reactant | 5-Fluoro-3-[(4-fluoro-2-methylphenyl)(4-fluorophenyl)methyl]-7-[(methylsulfanyl)methyl]-1H-indole | HCID 58392220 | — |
| Product | 5-Fluoro-3-[(4-fluoro-2-methylphenyl)(4-fluorophenyl)methyl]-7-[(methylsulfinyl)methyl]-1H-indole | HCID 58392191 | — |
Reaction Steps
The title compound was prepared starting from 75 mg (0.18 mmol) of the compound from Example 292 in analogy to the synthesis of the compound from Example 296. 75 mg (96% of theory) of the target compound were obtained as mixture of diastereomers.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08063234B2 |
| Source dataset | uspto-grants-2011_11 |
| ORD ID | ord-ea007ea61bb24a77ac89dc3fb71d84ad |
| Source note | uspto-grants-2011_11 |