3-[Bis(4-chlorophenyl)methyl]-7-[(methylsulfonyl)methyl]-1H-indole → 3-[(4-Chlorophenyl)(4-methoxyphenyl)methyl]-7-[(methylsulfonyl)methyl]-1H-indole

HRID 561722Notes

Reaction equation

HRID 561722 reaction equation
ClC1C=CC(C(C2C=C[C:24]([O:27]C)=CC=2)C2C3C(=C(CSC)C=CC=3)NC=2)=CC=1.[Cl:29][C:30]1[CH:35]=[CH:34][C:33]([CH:36]([C:51]2[CH:56]=[CH:55][C:54](Cl)=[CH:53][CH:52]=2)[C:37]2[C:45]3[C:40](=[C:41]([CH2:46][S:47]([CH3:50])(=[O:49])=[O:48])[CH:42]=[CH:43][CH:44]=3)[NH:39][CH:38]=2)=[CH:32][CH:31]=1>>[Cl:29][C:30]1[CH:35]=[CH:34][C:33]([CH:36]([C:51]2[CH:56]=[CH:55][C:54]([O:27][CH3:24])=[CH:53][CH:52]=2)[C:37]2[C:45]3[C:40](=[C:41]([CH2:46][S:47]([CH3:50])(=[O:49])=[O:48])[CH:42]=[CH:43][CH:44]=3)[NH:39][CH:38]=2)=[CH:32][CH:31]=1

Participants

3

Reactant 2

HCID 583923823-[Bis(4-chlorophenyl)methyl]-7-[(methylsulfonyl)methyl]-1H-indoleHCID 583924453-[(4-Chlorophenyl)(4-methoxyphenyl)methyl]-7-[(methylsulfanyl)methyl]-1H-indole

Product 1

HCID 583924833-[(4-Chlorophenyl)(4-methoxyphenyl)methyl]-7-[(methylsulfonyl)methyl]-1H-indole

Procedure

The title compound was prepared starting from 150 mg (0.37 mmol) of the compound from Example 282 in analogy to the synthesis of the compound from Example 312. 130 mg (80% of theory) of the target compound were obtained.

Workup

  1. custom130 mg (80% of theory) of the target compound were obtained

Sources & evidence

ORD record
ord-4d3bad5181b441509b5a26efbe1198ee
Source dataset
uspto-grants-2011_11
Patent number
US08063234B2

Reaction notes

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