HCID 86761443, compound → HCID 54671156, compound

Participants

Reaction Steps

(E)-6-(4,4,5,5,5-pentafluoropentylthio)-N-(2-(4-(2-phenyl-1-(4-(triisopropylsilyloxy)phenyl)but-1-enyl)phenoxy)ethyl)hexan-1-amine from reaction 6 is dissolved in acetonitrile. To this solution is added HF/pyridine complex. The mixture is stirred until the reaction is complete (TLC). When the reaction is complete, the mixture is washed with dilute hydrochloric acid, dilute sodium bicarbonate and water. The aqueous layers are extracted with ethyl acetate. The combined organic extracts are dried over sodium sulfate, filtered, and concentrated under reduced pressure to afford (Z)-4-(1-(4-(2-(6-(4,4,5,5,5-pentafluoropentylthio)hexylamino)ethoxy)phenyl)-2-phenylbut-1-enyl)phenol among other products.

Provenance & Evidence