Potassium Carbonate → HCID 57857053, compound

Participants

Reaction Steps

(3aR,4R,5R,6aS)-4-(3,3-Difluoro-4-phenoxybutyl)-2-oxohexahydro-2H-cyclopenta[b]furan-5-yl benzoate (prepared in Step C, 1.0 g, 2.4 mmol) is dissolved in methanol (0.2 M) and potassium carbonate (194 mg, 1.41 mmol) is added. The reaction mixture is stirred at room temperature and the progress is monitored by TLC every 30 minutes. After complete consumption of starting material, the reaction mixture is acidified with 5% KHSO4 and diluted with brine. The product is extracted with ethyl acetate twice. The combined organic layers are dried over sodium sulfate, filtered and evaporated. The crude product is purified by flash chromatography on regular silica gel eluted with ethyl acetate-hexanes (1:1) to afford the title intermediate.

Provenance & Evidence