HCID 57857014, compound → HCID 57857000, compound

Participants

Reaction Conditions

Reaction Steps

(Z)-7-((1R,2R,3R,5S)-2-(3,3-Difluoro-4-phenoxybutyl)-5-hydroxy-3-(tetrahydro-2H-pyran-2-yloxy)cyclopentyl)hept-5-enoic acid (limiting reagent, prepared in Step G) is dissolved in DCM (0.05 M) and cooled to 0° C. PCC (2 molar equivalents) is added and the reaction mixture is allowed to warm to room temperature with stirring. Upon completion by as indicated by TLC, the crude product is purified by flash chromatography on regular silica gel using ethyl acetate-hexane-acetic acid as eluent to afford the title intermediate.

Provenance & Evidence