反应详情

To a solution of 2-fluoro-N-hexyl-4-nitroaniline (4.37 g, 18.2 mmol) in MeOH (50 mL) was added catalyst Pd/C (0.50 g). The reaction mixture was stirred at rt under H2 overnight. The mixture was filtered, and the filtrate was concentrated in vacuo. The residue was purified by a silica gel column chromatography (PE/EtOAc (V/V)=4:1) to give the title compound as blackish oil (3.36 g, 88%).

1. filtrationThe mixture was filtered
2. concentrationthe filtrate was concentrated in vacuo
3. customThe residue was purified by a silica gel column chromatography (PE/EtOAc (V/V)=4:1)