Triacetoxyperiodinane → HCID 86635916, compound

Participants

Reaction Steps

To a solution of [2-(3-methoxypropyl)quinoline-4-yl]methanol from the previous step (1 eq.) in CH2Cl2 (0.05 M) was added Dess-Martin periodinane (1.1 eq.) portionwise. The resulting suspension was stirred at RT for 3 h. The reaction was quenched with MeOH and H2O. The organic layer was separated and the aqueous layer was back-extracted with EtOAc. The combined organic extracts were washed sat. aq. NaHCO3 and brine, dried over Na2SO4 and filtered. Concentration of the filtrate in vacuo afforded the title compound which was purified further by way of flash chromatography (SiO2, 2:1 (v/v) Hex:EtOAc).

Provenance & Evidence