N-Cyclopropyl-2-methoxy-6-[(1E)-3-methoxyprop-1-en-1-yl]isonicotinamide → N-Cyclopropyl-2-methoxy-6-(3-methoxypropyl)isonicotinamide

HRID 561833노트

반응식

HRID 561833 반응식
[CH:1]1([NH:4][C:5](=[O:19])[C:6]2[CH:11]=[C:10](/[CH:12]=[CH:13]/[CH2:14][O:15][CH3:16])[N:9]=[C:8]([O:17][CH3:18])[CH:7]=2)[CH2:3][CH2:2]1>CCOC(C)=O.[Pd]>[CH:1]1([NH:4][C:5](=[O:19])[C:6]2[CH:11]=[C:10]([CH2:12][CH2:13][CH2:14][O:15][CH3:16])[N:9]=[C:8]([O:17][CH3:18])[CH:7]=2)[CH2:3][CH2:2]1

참가 물질

4

반응물 1

HCID 66760917N-Cyclopropyl-2-methoxy-6-[(1E)-3-methoxyprop-1-en-1-yl]isonicotinamide

생성물 1

HCID 66761877N-Cyclopropyl-2-methoxy-6-(3-methoxypropyl)isonicotinamide

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 8857Ethyl Acetate용매

실험 절차

To a solution of N-cyclopropyl-2-methoxy-6-[(1E)-3-methoxyprop-1-en-1-yl]isonicotinamide from the previous step (1 eq.) in EtOAc (0.2 M) was added palladium (10% w/w over activated carbon, 15% loading). The reaction vessel was evacuated and back-filled with hydrogen. The reaction suspension was then stirred under a balloon atmosphere of hydrogen for 4 h. The reaction was quenched with CH2Cl2, filtered through celite and the insolubles washed further with EtOAc. Concentration of the filtrate in vacuo afforded the title compound as a white solid.

후처리

  1. customThe reaction vessel was evacuated
  2. additionback-filled with hydrogen
  3. customThe reaction was quenched with CH2Cl2
  4. filtrationfiltered through celite
  5. washthe insolubles washed further with EtOAc

출처 및 근거

ORD 기록
ord-767000ac58694576bb9e7fabdc74f561
출처 데이터셋
uspto-grants-2011_11
특허 번호
US08063105B2

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