反应详情

To a solution of N-cyclopropyl-2-methoxy-6-[(1E)-3-methoxyprop-1-en-1-yl]isonicotinamide from the previous step (1 eq.) in EtOAc (0.2 M) was added palladium (10% w/w over activated carbon, 15% loading). The reaction vessel was evacuated and back-filled with hydrogen. The reaction suspension was then stirred under a balloon atmosphere of hydrogen for 4 h. The reaction was quenched with CH2Cl2, filtered through celite and the insolubles washed further with EtOAc. Concentration of the filtrate in vacuo afforded the title compound as a white solid.

1. customThe reaction vessel was evacuated
2. additionback-filled with hydrogen
3. customThe reaction was quenched with CH2Cl2
4. filtrationfiltered through celite
5. washthe insolubles washed further with EtOAc