Formaldehyde → HCID 15981118, compound

HRID 561853Notes

Reaction equation

HRID 561853 reaction equation
[NH2:1][CH2:2][CH:3]([CH2:19][C:20]1[CH:25]=[CH:24][C:23]([CH2:26][CH2:27][CH2:28][O:29][C:30]2[C:35]([F:36])=[CH:34][CH:33]=[C:32]([F:37])[C:31]=2[Cl:38])=[CH:22][CH:21]=1)[C:4]([N:6]([CH:16]1[CH2:18][CH2:17]1)[CH2:7][C:8]1[CH:13]=[CH:12][CH:11]=[C:10]([Cl:14])[C:9]=1[Cl:15])=[O:5].[CH2:39]=O>>[Cl:38][C:31]1[C:32]([F:37])=[CH:33][CH:34]=[C:35]([F:36])[C:30]=1[O:29][CH2:28][CH2:27][CH2:26][C:23]1[CH:24]=[CH:25][C:20]([CH2:19][CH:3]([CH2:2][NH:1][CH3:39])[C:4]([N:6]([CH:16]2[CH2:17][CH2:18]2)[CH2:7][C:8]2[CH:13]=[CH:12][CH:11]=[C:10]([Cl:14])[C:9]=2[Cl:15])=[O:5])=[CH:21][CH:22]=1

Participants

3

Reactant 2

HCID 712FormaldehydeHCID 15981186HCID 15981186, compound

Product 1

HCID 15981118HCID 15981118, compound

Procedure

Prepared according to the procedure described in Example 19 but using instead 3-amino-2-{4-[3-(2-chloro-3,6-difluorophenoxy)propyl]benzyl}-N-cyclopropyl-N-(2,3-dichlorobenzyl)propanamide (Example 15) and paraformaldehyde. The title compound was obtained as a colorless oil. MS (ESI+): 595.3.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-9031e9b305614e06920e72ee1335c7e4
Source dataset
uspto-grants-2011_11
Patent number
US08063105B2

Reaction notes

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