HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 3-Amino-N-cyclopropyl-2-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]benzyl}-N-{3-(3-methoxypropyl)-5-[(1-oxidopyridin-2-yl)methoxy]benzyl}propanamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Tert-butyl (3-(cyclopropyl {3-(3-methoxypropyl)-5-[(1-oxidopyridin-2-yl)methoxy]benzyl}amino)-2-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]benzyl}-3-oxopropyl)carbamate | HCID 86635938 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 3-Amino-N-cyclopropyl-2-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]benzyl}-N-{3-(3-methoxypropyl)-5-[(1-oxidopyridin-2-yl)methoxy]benzyl}propanamide | HCID 15981287 | — |
Reaction Steps
To a CH2Cl2 solution (0.03 M) of tert-butyl (3-(cyclopropyl{3-(3-methoxypropyl)-5-[(1-oxidopyridin-2-yl)methoxy]benzyl}amino)-2-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]benzyl}-3-oxopropyl)carbamate from the previous step (1 eq.) was added HCl (4.0 M dioxane solution, 20 eq.).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08063105B2 |
| Source dataset | uspto-grants-2011_11 |
| ORD ID | ord-c93c50d8985548008839791f13959095 |
| Source note | uspto-grants-2011_11 |