Acetic Acid → HCID 178494885, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of tert-butyl (3-[[3-(3-cyanopropoxy)-5-(3-methoxypropyl)benzyl](cyclopropyl)amino]-2-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]benzyl}-3-oxopropyl)carbamate from Example 74 in dichlorobenzene (0.08 M) was added azidotributyltin (2 eq.). The resulting mixture was heated to 150° C. for 22 h. The reaction was quenched with glacial acetic acid (6 eq.) and directly loaded onto a silica gel column packed with 85:15 (v/v) CH2Cl2: 2.0 M NH3 in MeOH. Elution with the same solvent system afforded the title compound as a yellow oil. MS (ESI+): 725.4.

Provenance & Evidence