Hydrochloric Acid → HCID 57956118, compound

Participants

Reaction Steps

To a CH2Cl2 solution (0.09 M) of tert-butyl (3-[cyclopropyl(pyridin-4-ylmethyl)amino]-2-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]benzyl}-3-oxopropyl)carbamate from the previous step (I eq.) was added HCl (4.0 M dioxane solution, 46 eq.). The resulting solution was stirred at RT for 5 h. The reaction was quenched with 2.0 M NH3 in MeOH and concentrated in vacuo. The resulting residue was directly loaded onto a SiO2 column packed with 90:9:1 (v/v) CH2Cl2:MeOH:conc. NH4OH. Elution with the same solvent system furnished the title compound. MS (ESI+): 527.9.

Provenance & Evidence