Hydrochloric Acid → HCID 57956071, compound

Participants

Reaction Steps

To a CH2Cl2 solution (0.1 M) of tert-butyl [3-[[2-chloro-5-(3-methoxypropyl)benzyl](cyclopropyl)amino]-2-(4-{2-[2,6-dichloro-4-(3-hydroxypropyl)phenoxy]ethoxy}benzyl}-3-oxopropyl]carbamate from the previous step (1 eq.) was added HCl (4.0 M dioxane solution, 35 eq.). The resulting solution was stirred at RT for 4 h. The reaction was quenched with 2.0 M NH3 in MeOH and concentrated in vacuo. The resulting residue was directly loaded onto a SiO2 column packed with 90:9:1 (v/v) CH2Cl2:MeOH:conc. NH4OH. Elution with the same solvent system furnished the title compound. MS (ESI+): 677.2.

Provenance & Evidence