反应详情

To a solution of 1-(2-fluoro-4-iodo-phenyl)-ethanol (15.50 g, 58.26 mmol) in dichloromethane (250 mL) was added manganese dioxide (101.26 g, 1.17 mole) and the reaction mixture was heated to reflux for 24 hours. The reaction mixture was cooled, filtered through a pad of celite coated with a thin layer of silica gel and concentrated in vacuo to give 1-(2-fluoro-4-iodo-phenyl)-ethanone (14.04 g, 91%).

1. temperaturethe reaction mixture was heated
2. temperatureto reflux for 24 hours
3. temperatureThe reaction mixture was cooled
4. filtrationfiltered through a pad of celite coated with a thin layer of silica gel
5. concentrationconcentrated in vacuo