HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Chlorosuccinimide → HCID 178432851, Verbindung
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Chlorosuccinimide | HCID 31398 | — |
| Edukt | (R)-2-((tert-Butoxycarbonyl)amino)-3-cyclopropylpropanoic acid | HCID 2756015 | — |
| Edukt | 3-((R)-1-{(S)-1-[5-(4-iodo-phenyl)-1H-imidazol-2-yl]-2-methyl-propyl}-2,5-dioxo-imidazolidin-4-yl)-propionic acid | HCID 57771978 | — |
| Edukt | (R)-tert-butoxycarbonylamino-(4-dimethylcarbamoylmethoxy-phenyl)-acetic acid | HCID 66815126 | — |
| Edukt | 1-(2-Fluoro-4-iodophenyl)propan-1-one | HCID 67001546 | — |
| Produkt | HCID 178432851 | HCID 178432851 | — |
Reaktionsschritte
Prepared by the same method as described in example 1 except that (i) steps A, B and C were omitted; (ii) 1-(2-fluoro-4-iodo-phenyl)-propan-1-one (prepared as described below) was used in place of 1-(2-fluoro-4-iodo-phenyl)-ethanone in step 13-D; (iii) chlorination of the 5-position of the imidazole ring with N-chlorosuccinimide in step 13-F was omitted, and (iv) in step 13-G commercially available (R)-2-tert-butoxycarbonylamino-3-cyclopropyl-propionic acid was used in place of (R)-tert-butoxycarbonylamino-[4-(2-tert-butoxy-ethoxy)-phenyl]-acetic acid.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US08063085B2 |
| Quelldatensatz | uspto-grants-2011_11 |
| ORD ID | ord-14db1c2a025a452dbe2b3c431ff02f52 |
| Quellennotiz | uspto-grants-2011_11 |