HuagongsheHuagongshe Chemistry Print Report · For research reference only
Chlorosuccinimide → HCID 178432846, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Chlorosuccinimide | HCID 31398 | — |
| Reactant | 2-Chloro-1,4-diiodobenzene | HCID 53406555 | — |
| Reactant | 3-((R)-1-{(S)-1-[5-(4-iodo-phenyl)-1H-imidazol-2-yl]-2-methyl-propyl}-2,5-dioxo-imidazolidin-4-yl)-propionic acid | HCID 57771978 | — |
| Reactant | (R)-tert-butoxycarbonylamino-(4-dimethylcarbamoylmethoxy-phenyl)-acetic acid | HCID 66815126 | — |
| Reactant | (R)-tert-Butoxycarbonylamino-[4-((S)-2,2-dimethyl-[1,3]dioxolan-4-ylmethoxy)-phenyl]-acetic acid | HCID 67001404 | — |
| Reactant | HCID 178418443 | HCID 178418443 | — |
| Reactant | HCID 178432851 | HCID 178432851 | — |
| Product | HCID 178432846 | HCID 178432846 | — |
Reaction Steps
Prepared by the same method as described in example 1 except that (i) in step 95-A 2-chloro-1,4-diiodo-benzene was used in place of 2-fluoro-1,4-diiodo-benzene; (ii) in step 95-B ethylmagnesium bromide was used in place of methylmagnesium chloride; (iii) chlorination of the 5-position of the imidazole ring with N-chlorosuccinimide in step 95-F was omitted, and (iv) (R)-tert-butoxycarbonylamino-[4-((S)-2,2-dimethyl-[1,3]dioxolan-4-ylmethoxy)-phenyl]-acetic acid (prepared as described in steps 33-T and 33-U) was used in place of (R)-tert-butoxycarbonylamino-[4-(2-tert-butoxy-ethoxy)-phenyl]-acetic acid in step 95-G. HR-MS: calcd for C31H30ClIN4O5 [M+H+] 701.1022. Found 701.1017.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08063085B2 |
| Source dataset | uspto-grants-2011_11 |
| ORD ID | ord-ed54bd9695704eab924b1d672593ca1d |
| Source note | uspto-grants-2011_11 |