HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Chlorosuccinimide → (r)-3-{(s)-1-[5-(4-Bromo-phenyl)-4-methyl-1h-imidazol-2-yl]-2-phenyl-ethyl}-5-[4-(2-hydroxy-ethoxy)-phenyl]-imidazolidine-2,4-dione
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Chlorosuccinimide | HCID 31398 | — |
| Edukt | p-Bromopropiophenone | HCID 66312 | — |
| Edukt | 3-((R)-1-{(S)-1-[5-(4-iodo-phenyl)-1H-imidazol-2-yl]-2-methyl-propyl}-2,5-dioxo-imidazolidin-4-yl)-propionic acid | HCID 57771978 | — |
| Edukt | (R)-tert-butoxycarbonylamino-(4-dimethylcarbamoylmethoxy-phenyl)-acetic acid | HCID 66815126 | — |
| Edukt | HCID 178432851 | HCID 178432851 | — |
| Produkt | (r)-3-{(s)-1-[5-(4-Bromo-phenyl)-4-methyl-1h-imidazol-2-yl]-2-phenyl-ethyl}-5-[4-(2-hydroxy-ethoxy)-phenyl]-imidazolidine-2,4-dione | HCID 178432844 | — |
Reaktionsschritte
Prepared by the same method as described in example 1 except that (i) steps A, B and C were omitted; (ii) commercially available 1-(4-bromo-phenyl)-propan-1-one was used in place of 1-(2-fluoro-4-iodo-phenyl)-ethanone in step 105-D; (iii) (S)-2-tert-butoxycarbonylamino-3-phenyl-propionic acid was used in place of (2S,3S)-2-tert-butoxycarbonylamino-3-phenyl-butyric acid in step 105-E and (iv) chlorination of the 5-position of the imidazole ring with N-chlorosuccinimide in step 105-F was omitted. HR-MS: calcd for C29H27BrN4O4 [M+H+] 575.1289. Found 575.1286.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US08063085B2 |
| Quelldatensatz | uspto-grants-2011_11 |
| ORD ID | ord-2ec1eb78923b4879a51523e321442b6c |
| Quellennotiz | uspto-grants-2011_11 |