HuagongsheHuagongshe Chemistry Print Report · For research reference only
Chlorosuccinimide → HCID 178432847, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Chlorosuccinimide | HCID 31398 | — |
| Reactant | p-Bromopropiophenone | HCID 66312 | — |
| Reactant | 3-((R)-1-{(S)-1-[5-(4-iodo-phenyl)-1H-imidazol-2-yl]-2-methyl-propyl}-2,5-dioxo-imidazolidin-4-yl)-propionic acid | HCID 57771978 | — |
| Reactant | (R)-tert-butoxycarbonylamino-(4-dimethylcarbamoylmethoxy-phenyl)-acetic acid | HCID 66815126 | — |
| Reactant | HCID 178432851 | HCID 178432851 | — |
| Product | HCID 178432847 | HCID 178432847 | — |
Reaction Steps
Prepared by the same method as described in example 1 except that (i) steps A, B and C were omitted; (ii) commercially available 1-(4-bromo-phenyl)-propan-1-one was used in place of 1-(2-fluoro-4-iodo-phenyl)-ethanone in step 106-D and (iii) chlorination of the 5-position of the imidazole ring with N-chlorosuccinimide in step 106-F was omitted. HR-MS: calcd for C30H29BrN4O4 [M+H+] 589.1445. Found 589.1444.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08063085B2 |
| Source dataset | uspto-grants-2011_11 |
| ORD ID | ord-71e71ee29d2848ada74e188385d8754e |
| Source note | uspto-grants-2011_11 |