HRID562079

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID674

Dimethylamine

C2H7N

结构：CCS(=O)(=O)N1CCC(c2c[nH]c3c(C(N)=O)cc(-c4cc(CN(C)C)c(OC)c(OC)c4)cc23)CC1

HCID16037307

未命名化合物

PRODUCTS

生成物

结构：CCS(=O)(=O)N1CCC(c2c[nH]c3c(C(N)=O)cc(-c4cc(CNCC(C)(C)C)c(OC)c(OC)c4)cc23)CC1

HCID16037310

未命名化合物

收率 29.2%

PROCEDURE

实验过程

The title compound was prepared according to the general procedure of 5-[3-[(dimethylamino)methyl]-4,5-bis(methyloxy)phenyl]-3-[1-(ethylsulfonyl)-4-piperidinyl]-1H-indole-7-carboxamide, substituting (2,2-dimethylpropyl)amine (20 μL, 0.30 mmol) for dimethylamine to afford 10 mg of the title compound (29.2%).

WORKUP

后处理

customThe title compound was prepared

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-451181feaed8400a83064a896c994f58
来源数据集: uspto-grants-2011_11
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08063071B2
来源说明: uspto-grants-2011_11

反应 SMILES

C[N:2]([CH2:4][C:5]1[CH:6]=[C:7]([C:15]2[CH:16]=[C:17]3[C:21](=[C:22]([C:24]([NH2:26])=[O:25])[CH:23]=2)[NH:20][CH:19]=[C:18]3[CH:27]2[CH2:32][CH2:31][N:30]([S:33]([CH2:36][CH3:37])(=[O:35])=[O:34])[CH2:29][CH2:28]2)[CH:8]=[C:9]([O:13][CH3:14])[C:10]=1[O:11][CH3:12])[CH3:3].CNC>>[CH3:4][C:5]([CH3:6])([CH3:10])[CH2:3][NH:2][CH2:4][C:5]1[CH:6]=[C:7]([C:15]2[CH:16]=[C:17]3[C:21](=[C:22]([C:24]([NH2:26])=[O:25])[CH:23]=2)[NH:20][CH:19]=[C:18]3[CH:27]2[CH2:28][CH2:29][N:30]([S:33]([CH2:36][CH3:37])(=[O:35])=[O:34])[CH2:31][CH2:32]2)[CH:8]=[C:9]([O:13][CH3:14])[C:10]=1[O:11][CH3:12]