N-Methylethylamine → HCID 66722977, compound

HRID 562090Notes

Reaction equation

HRID 562090 reaction equation
[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].[CH2:8]([N:10]([CH2:12][C:13]1[S:17][CH:16]=[C:15]([C:18]2[CH:19]=[C:20]3[C:24](=[C:25]([C:27]([NH2:29])=[O:28])[CH:26]=2)[NH:23][CH:22]=[C:21]3[CH:30]2[CH2:35][CH2:34][N:33]([S:36]([CH2:39][CH3:40])(=[O:38])=[O:37])[CH2:32][CH2:31]2)[CH:14]=1)[CH3:11])[CH3:9].CN[CH2:43][CH3:44]>>[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].[CH:8]1([N:10]([CH2:12][C:13]2[S:17][CH:16]=[C:15]([C:18]3[CH:19]=[C:20]4[C:24](=[C:25]([C:27]([NH2:29])=[O:28])[CH:26]=3)[NH:23][CH:22]=[C:21]4[CH:30]3[CH2:35][CH2:34][N:33]([S:36]([CH2:39][CH3:40])(=[O:37])=[O:38])[CH2:32][CH2:31]3)[CH:14]=2)[CH3:11])[CH2:44][CH2:43][CH2:2][CH2:9]1

Participants

3

Reactant 2

HCID 12219N-MethylethylamineHCID 66723263HCID 66723263, compound

Product 1

HCID 66722977HCID 66722977, compoundYield 7.78%

Procedure

The title compound was prepared according to the general procedure of 5-(5-{[ethyl(methyl)amino]methyl}-3-thienyl)-3-[1-(ethylsulfonyl)-4-piperidinyl]-1H-indole-7-carboxamide trifluoroacetate, substituting cyclopentyl(methyl)amine (99 mg, 1.0 mmol) for N-methylethanamine to afford 5.0 mg of the title compound (7.78%).

Workup

  1. customThe title compound was prepared

Sources & evidence

ORD record
ord-20bcb0ff30ed43d6a0e0c6edbf3fe571
Source dataset
uspto-grants-2011_11
Patent number
US08063071B2

Reaction notes

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