Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 562105Generated: October 29, 2026

2-Propylpyrrolidine → 3-[1-(ethylsulfonyl)-4-piperidinyl]-5-(5-{[methyl(propyl)amino]methyl}-3-thienyl)-1H-indole-7-carboxamide

https://huagongshe.com/reaction/562105

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-PropylpyrrolidineHCID 3795961—
Reactant5-(5-{[ethyl(methyl)amino]methyl}-3-thienyl)-3-[1-(ethylsulfonyl)-4-piperidinyl]-1H-indole-7-carboxamideHCID 16037480—
Product3-[1-(ethylsulfonyl)-4-piperidinyl]-5-(5-{[methyl(propyl)amino]methyl}-3-thienyl)-1H-indole-7-carboxamideHCID 1603757063.7%

Reaction Steps

The title compound was prepared according to the general procedure of 5-(5-{[ethyl(methyl)amino]methyl}-3-thienyl)-3-[1-(ethylsulfonyl)-4-piperidinyl]-1H-indole-7-carboxamide, substituting methyl(propyl)amine (73 mg, 1.0 mmol) for 2-propylpyrrolidine to afford 32.0 mg of the title compound (63.7%).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08063071B2
Source datasetuspto-grants-2011_11
ORD IDord-e10d9b54ac5a4c1690c7614792f5b936
Source noteuspto-grants-2011_11