反应详情

Under nitrogen and while stirring there were added dropwise to a solution of 129.2 g of methyl (R)-3-hydroxytetradecanoate, 1033 ml of dioxan and 122.9 g of 28 percent sodium hydroxide solution. 77.5 ml of methanol were added dropwise to the solution. After stirring for a further 1.5 hours the resulting suspension was filtered and the filter cake was washed with 1000 ml of dioxan and filtered off. The filter cake was adjusted to pH 0 by the addition of 650 ml of 1.5N hydrochloric acid. The suspension was stirred, filtered, the filter cake was washed with 3000 ml of water and the crystals were dried. 119.64 g (98%) of (R)-3-hydroxytetradecanoic acid, m.p. 70.6°-71.4°, were obtained.

1. stirringAfter stirring for a further 1.5 hours the resulting suspension
2. filtrationwas filtered
3. washthe filter cake was washed with 1000 ml of dioxan
4. filtrationfiltered off
5. additionThe filter cake was adjusted to pH 0 by the addition of 650 ml of 1.5N hydrochloric acid
6. stirringThe suspension was stirred
7. filtrationfiltered
8. washthe filter cake was washed with 3000 ml of water
9. customthe crystals were dried