2-(3-Chlorophenyl)piperazine → HCID 66722935, compound

HRID 562255Notes

Reaction equation

HRID 562255 reaction equation
[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].[CH2:8]([S:10]([N:13]1[CH2:18][CH2:17][CH:16]([C:19]2[C:27]3[C:22](=[C:23]([C:40]([NH2:42])=[O:41])[CH:24]=[C:25](C4C=CC=C(C5CNCCN5)C=4)[CH:26]=3)[NH:21][CH:20]=2)[CH2:15][CH2:14]1)(=[O:12])=[O:11])[CH3:9].Cl[C:44]1[CH:45]=[C:46]([CH:50]2CNC[CH2:52][NH:51]2)[CH:47]=[CH:48][CH:49]=1>>[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].[CH2:8]([S:10]([N:13]1[CH2:18][CH2:17][CH:16]([C:19]2[C:27]3[C:22](=[C:23]([C:40]([NH2:42])=[O:41])[CH:24]=[C:25]([C:45]4[CH:44]=[CH:49][CH:48]=[CH:47][C:46]=4[CH2:50][NH:51][CH3:52])[CH:26]=3)[NH:21][CH:20]=2)[CH2:15][CH2:14]1)(=[O:11])=[O:12])[CH3:9]

Participants

3

Reactant 2

HCID 52256382-(3-Chlorophenyl)piperazineHCID 66723273HCID 66723273, compound

Product 1

HCID 66722935HCID 66722935, compoundYield 19.8%

Procedure

The title compound was prepared according to the general procedure of 3-[1-(ethylsulfonyl)-4-piperidinyl]-5-[3-(2-piperazinyl)phenyl]-1H-indole-7-carboxamide trifluoroacetate, substituting 1-(2-bromophenyl)-N-methylmethanamine (65 mg, 0.325 mmol) for 2-(3-chlorophenyl)piperazine to afford 14.6 mg of the title compound (19.8%).

Workup

  1. customThe title compound was prepared

Sources & evidence

ORD record
ord-1c4c502d46154c359aed4bffb6d9adaa
Source dataset
uspto-grants-2011_11
Patent number
US08063071B2

Reaction notes

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