反应详情

Using Methyl cyclohexanecarboxylate (5.55 g), KHMDS (100 ml of a 0.5M solution in toluene), anhydrous THF (100 ml) and benzyl 2-bromoethyl ether (10.09 g) and the procedure set forth previously (Example 108, Step 1), the desired intermediate benzyl ether (6.83 g) was obtained after silica gel column chromatography (EtOAc:Hexanes: 15:85).