HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 562453Generated: October 30, 2026
Sodium Hydroxide → 1-(6-Chloropyrimidin-4-yl)azetidin-3-ol
https://huagongshe.com/reaction/562453
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 4,6-Dichloropyrimidine | HCID 70943 | — |
| Reactant | 3-Hydroxyazetidine | HCID 1514290 | — |
| Solvent | Water | HCID 962 | — |
| Product | 1-(6-Chloropyrimidin-4-yl)azetidin-3-ol | HCID 57925079 | — |
Reaction Steps
7.3 g (48.7 mmol) of 4,6-dichloropyrimidine are suspended in 140 ml of water, and 47 ml 1 N aqueous sodium hydroxide solution are added. 5.3 g (48.7 mmol) of 3-hydroxyazetidine are added, and the reaction mixture is stirred at 90° C. for 3 d. After cooling to RT, the reaction mixture is concentrated under reduced pressure and reacted further without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08067407B2 |
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| Source dataset | uspto-grants-2011_11 |
|---|
| ORD ID | ord-9ac6158955864f2aa78d7c64f0ec1ce0 |
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| Source note | uspto-grants-2011_11 |
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