反应详情

55 mg (0.4 mmol) of azetidine-3-carboxylic acid hydrochloride are initially charged in 2 ml of water. 100 mg (0.3 mmol) of the compound from Example 12A are added, and the pH is adjusted to 7 using aqueous 1 N sodium hydroxide solution. The mixture is reacted in a single mode microwave (Emrys Optimizer) at 150° C. for 1 h. The reaction mixture is concentrated under reduced pressure and purified by preparative HPLC (RP18 column; mobile phase: acetonitrile/water gradient). Yield: 15 mg (13% of theory)

1. customThe mixture is reacted in a single mode microwave (Emrys Optimizer) at 150° C. for 1 h
2. concentrationThe reaction mixture is concentrated under reduced pressure
3. custompurified by preparative HPLC (RP18 column; mobile phase: acetonitrile/water gradient)