HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → 6-Amino-2-butoxy-9-{3-[[4-(methylsulfonyl)benzyl] (3-morpholin-4-ylpropyl)amino]propyl}-7,9-dihydro-8H-purin-8-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 4-(Methylsulfonyl)benzyl Bromide | HCID 2733581 | — |
| Reactant | 6-Amino-2-butoxy-9-[3-(3-morpholin-4-yl-propylamino)-propyl]-7,9-dihydro-purin-8-one | HCID 66962280 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 6-Amino-2-butoxy-9-{3-[[4-(methylsulfonyl)benzyl] (3-morpholin-4-ylpropyl)amino]propyl}-7,9-dihydro-8H-purin-8-one | HCID 24964687 | — |
Reaction Steps
The product from example 1 step (viii) (0.1 g), 4-methylsulphonylbenzyl bromide (0.0673 g) and potassium carbonate (0.0373 g) were combined in DMF (1.5 mL) and stirred at RT for 15 hrs. The reaction mixture was diluted with methanol filtered and purified by RPHPLC to give title compound, 0.039 g
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08067411B2 |
| Source dataset | uspto-grants-2011_11 |
| ORD ID | ord-e81a7ee5608d4adc97f5f34f6314d178 |
| Source note | uspto-grants-2011_11 |