HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 562495Generated: October 30, 2026
Ammonia → 2-Chloro-9-(tetrahydropyran-2-yl)adenine
https://huagongshe.com/reaction/562495
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | 2,6-Dichloro-9-(tetrahydro-2H-pyran-2-yl)-9H-purine | HCID 270265 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 2-Chloro-9-(tetrahydropyran-2-yl)adenine | HCID 12777819 | — |
Reaction Steps
2,6-Dichloro-9-(tetrahydro-2H-pyran-2-yl)-9H-purine (55 g) was dissolved in 7N-aqueous ammonia in MeOH (500 ml) and heated at 100° C. in a sealed flask for 6 h. The reaction mixture was cooled to rt and left overnight. Filtration afforded the subtitle compound. Yield 40 g.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08067413B2 |
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| Source dataset | uspto-grants-2011_11 |
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| ORD ID | ord-dee84dd45d0140efa072b026fc752935 |
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| Source note | uspto-grants-2011_11 |
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