HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pyrrolidine → 6-Amino-2-butoxy-9-(3-pyrrolidin-1-ylpropyl)-7,9-dihydro-8H-purin-8-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pyrrolidine | HCID 31268 | — |
| Reactant | 6-Amino-9-(3-chloropropyl)-2-butoxy-7,9-dihydro-8H-purin-8-one | HCID 67464941 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | 6-Amino-2-butoxy-9-(3-pyrrolidin-1-ylpropyl)-7,9-dihydro-8H-purin-8-one | HCID 25072077 | 26.3% |
Reaction Steps
The product from step (vii) (0.15 g) was dissolved in DMSO (2 mL) and pyrrolidine (0.18 g) was added. The reaction mixture was stirred at rt for 16 h. The reaction mixture was filtered through a filter disc and purified via RP-prep-HPLC to give title compound (0.044 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08067413B2 |
| Source dataset | uspto-grants-2011_11 |
| ORD ID | ord-4a80583b4c8b4cc0b94d24fd70dff0f7 |
| Source note | uspto-grants-2011_11 |