反应详情

温度

40 °C

To a solution of KOH (0.24 g, 4.28 mmol) in mixed solvents of water (3 mL) and ethanol (3 mL) under N2 was added ethyl 4-(3-fluorophenoxy)butanoate (0.30 g, 1.33 mmol) in one portion and the mixture was stirred at 40° C. for 4 h. It was then cooled to rt and 20 mL of DCM was added. The organic layer was washed with brine (20 mL×2), dried over anhydrous Na2SO4 and concentrated in vacuo to give the title compound as a white solid (0.25 g, 96%).

1. temperatureIt was then cooled to rt
2. washThe organic layer was washed with brine (20 mL×2)
3. dry with materialdried over anhydrous Na2SO4
4. concentrationconcentrated in vacuo