HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetonitrile--water (1/1) → 17-(tert-Butoxy)-17-oxoheptadecanoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetonitrile--water (1/1) | HCID 18373917 | — |
| Reactant | 4-{[(2-tert-Butoxycarbonylethyl)-(16-tert-butoxycarbonylhexadecanoyl)-amino]methyl}benzoic acid 2,5-dioxopyrrolidin-1-yl ester | HCID 58079473 | — |
| Product | 17-(tert-Butoxy)-17-oxoheptadecanoic acid | HCID 58079486 | — |
Reaction Steps
4-{[(2-tert-Butoxycarbonylethyl)-(16-tert-butoxycarbonylhexadecanoyl)-amino]methyl}benzoic acid 2,5-dioxopyrrolidin-1-yl ester was reacted with A1,B1-diBoc desB30 insulin as described in general procedure B. The work up was similar using a gradient 28-48% acetonitrile/water containing 0.1% TFA.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08067362B2 |
| Source dataset | uspto-grants-2011_11 |
| ORD ID | ord-2c97e6c8badb4d70adadfa48889a1b38 |
| Source note | uspto-grants-2011_11 |