HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → 4-[(15-Tert-butoxycarbonylpentadecanoylamino)methyl]benzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | 4-(Aminomethyl)Benzoic Acid | HCID 65526 | — |
| Reactant | 1-tert-Butyl 16-(2,5-dioxopyrrolidin-1-yl) hexadecanedioate | HCID 59562807 | — |
| Solvent | N-methyl-2-pyrrolidone | HCID 13387 | — |
| Product | 4-[(15-Tert-butoxycarbonylpentadecanoylamino)methyl]benzoic acid | HCID 59687910 | 65.8% |
Reaction Steps
To 4-(Aminomethyl)benzoic acid (0.2 g, 1.32 mmol) was added in NMP (5 mL). Hexadecanedioic acid tert-butyl ester 2,5-dioxo-pyrrolidin-1-yl ester (0.58 g, 1.32 mmol) was added and the mixture was stirred at room temperature overnight. The mixture was poured into water (100 mL), the precipitate was isolated by filtration and dried in vacuo. The crude material was recrystallized from toluene to give 4-[(15-tert-butoxycarbonylpentadecanoylamino)methyl]benzoic acid (413 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08067362B2 |
| Source dataset | uspto-grants-2011_11 |
| ORD ID | ord-d3a1e6cf16e84016b65969a10e52caed |
| Source note | uspto-grants-2011_11 |